A multisystem granulomatous disease: necrobiotic xanthogranuloma with hepatic involvement
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منابع مشابه
A multisystem granulomatous disease: necrobiotic xanthogranuloma with hepatic involvement.
Clinical record A 51-year-old woman was referred to hospital after an incidental fi nding of abnormal liver function test results (γ-glutamyl transpeptidase, 271 U/L [reference interval (RI), < 60 U/L]; alkaline phosphatase, 220 U/L [RI, 30–110 U/L]; hepatic transaminases, normal), acute renal impairment (urea, 11.7 mmol/L [RI, 2.7–8.0 mmol/L]; creatinine, 207 μmol/L [RI, 50–100 μmol/L]) and el...
متن کاملNecrobiotic xanthogranuloma with paraproteinemia without periorbital involvement—a case report
Necrobiotic xanthogranuloma is an uncommon granulomatous disease involving the skin and extracutaneous tissues. It is characterized by indurated, yellow-red plaques and nodules, involving primarily the face and less frequently the trunk and extremities. The disease has a strong association with paraproteinemia and other hematologic or lymphoproliferative disorders. Histologically, the dermal pa...
متن کامل[Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report].
CASE REPORT A 48-year-old male was referred to our hospital for further evaluation of eyelid edema with bilateral yellowish ulcerated nodules. Suspecting a xanthogranulomatosis, imaging tests and biopsy were performed with diagnosis of necrobiotic xanthogranuloma. IgG monoclonal gammapathy was diagnosed in a systemic study. Systemic corticosteroids and cyclosporine were initiated unsuccessfully...
متن کاملAtypical Necrobiotic Xanthogranuloma Associated with Epidermodysplasia Verruciformis
Necrobiotic xanthogranuloma is a rare, idiopathic, and chronic systemic granulomatous disorder that is usually associated with paraproteinemia of the immunoglobulin (Ig)G kappa (κ) type. It is clinically characterized by yellowish red-to-brown indurated often ulcerating nodules or plaques that usually involve the periorbital regions of the elderly. We report an atypical case of NXG affecting on...
متن کاملPhysiopathology of necrobiotic xanthogranuloma with monoclonal gammopathy
RATIONALE Xanthomatosis associated with monoclonal gammopathy includes hyperlipidaemic xanthoma (HX), normolipidaemic xanthoma (NX) and necrobiotic xanthogranuloma (NXG). All three pathologies are characterized by skin or visceral lesions related to cholesterol accumulation, monoclonal immunoglobulin (MIg) and hypocomplementemia. The pathophysiology underlying NXG remains unknown although the i...
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ژورنال
عنوان ژورنال: Medical Journal of Australia
سال: 2014
ISSN: 0025-729X,1326-5377
DOI: 10.5694/mja13.11303